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Differentiating patients with CRC from healthy controls using a ROC curve. To identify the optimal CTC threshold value for differentiating patients with CRC from healthy controls, the sensitivity and specificity were optimized using a threshold count of 5 CTCs per 7.5 mL of blood. Red line, reference line; Blue line, ROC curve; CTC, circulating tumor cell; AUC, area under the curve; CRC, colorectal cancer; ROC, receiver operating characteristic.
