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Maximum concentration of postprandial ProUGN at 90 minutes by (a) diagnosis (blue, healthy volunteers; red, patients with CIC; green, patients with IBS-C), (b) gender (dark shade, male; light shade, female), and (c) age (dark shade, ≤40 years; light shade, >40 years). CIC, chronic idiopathic constipation; IBS-C, irritable bowel syndrome with constipation; ProUGN, prouroguanylin.
