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Time course of postprandial changes in serum UGN concentrations by (a) cohorts (blue, healthy volunteers; yellow, all patients with constipation), (b) diagnosis (blue, healthy volunteers; red, patients with CIC; green, patients with IBS-C), (c) gender (blue, male; yellow, female), and (d) age (blue, ≤40 years; yellow, >40 years). CIC, chronic idiopathic constipation; IBS-C, irritable bowel syndrome with constipation; UGN, uroguanylin.
