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. 2019 Jul 1;10(7):e00058. doi: 10.14309/ctg.0000000000000058

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© 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 4. — TIM3 and LAG3 expressions are predominantly observed in PD1^high intratumoral CD8⁺ T cells in advanced HCC. (a) Representative flow cytometry plots of immune checkpoint molecules, including FMO controls. (b) Coexpression patterns of PD-1, TIM3, and LAG3 in the intratumoral T cells of patients with advanced HCC. FSC, forward scatter; FMO, fluorescence minus one; HCC, hepatocellular carcinoma; PD, programmed death.