Table 3.

Smoking abstinence: Subjective response (adjusted mean ± standard error) to nicotine nasal spray by oral contraceptive use and testing week

	Oral Contraceptive Users (n=14)	Naturally Cycling Participants (n=28)	Mean Difference*	p-value**
Anticipated Low Progesterone Week
Prior to Nicotine Nasal Spray
Positive Affect	2.48 ± 0.36	3.24 ± 0.28	−0.76 ± 0.40	0.072
Negative Affect†	1.70 ± 0.35	1.79 ± 0.25	−0.09 ± 0.44	0.835
Craving†	3.73 ± 0.58	3.89 ± 0.42	−0.16 ± 0.70	0.820
Withdrawal†	1.38 ± 0.26	1.28 ± 0.18	0.11 ± 0.32	0.743
Physical Symptoms	0.78 ± 0.17	0.60 ± 0.12	0.18 ± 0.21	0.389
After Nicotine Nasal Spray, Adjusted for Pre-Nasal Spray Level
Positive Affect†	3.02 ± 0.20	3.14 ± 0.14	−0.12 ± 0.25	0.637
Negative Affect	1.43 ± 0.18	1.39 ± 0.13	0.04 ± 0.22	0.853
Craving	3.12 ± 0.45	3.58 ± 0.35	−0.46 ± 0.50	0.365
Withdrawal	0.93 ± 0.12	1.05 ± 0.08	−0.13 ± 0.14	0.366
Physical Symptoms†	0.76 ± 0.12	0.73 ± 0.08	0.03 ± 0.15	0.847
Anticipated High Progesterone Week
Prior to Nicotine Nasal Spray
Positive Affect	2.25 ± 0.36	3.10 ± 0.27	−0.85 ± 0.42	0.056
Negative Affect†	1.63 ± 0.29	1.88 ± 0.20	−0.26 ± 0.36	0.482
Craving	3.49 ± 0.61	4.00 ± 0.49	−0.51 ± 0.65	0.436
Withdrawal†	1.17 ± 0.19	1.24 ± 0.13	−0.07 ± 0.24	0.766
Physical Symptoms	0.93 ± 0.15	0.59 ± 0.11	0.34 ± 0.17	0.057
After Nicotine Nasal Spray, Adjusted for Pre-Nasal Spray Level
Positive Affect†	2.84 ± 0.25	2.92 ± 0.17	−0.09 ± 0.31	0.787
Negative Affect	1.37 ± 0.19	1.32 ± 0.13	0.05 ± 0.24	0.844
Craving	3.00 ± 0.39	3.25 ± 0.29	−0.25 ± 0.45	0.588
Withdrawal	0.83 ± 0.12	1.03 ± 0.09	−0.20 ± 0.15	0.181
Physical Symptoms	0.59 ± 0.09	0.71 ± 0.07	−0.13 ± 0.10	0.234

^*(β ± Standard Error),

^**P-values are from linear mixed models with a random intercept for matched set and adjusted for FTND and study week order (post-nasal-spray models also adjusted for pre-nasal-spray SSS level), each row is its own model,

^†Random effect variance of 0 in linear mixed model.