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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: J Invest Dermatol. 2019 Mar 21;139(9):1985–1992.e10. doi: 10.1016/j.jid.2019.01.036

Figure 5. Effects of ABCB5 mutations on migratory and invasive abilities of melanoma cells.

Figure 5.

(a) 17T ABCB5 Q187*, S1091F, and S1184P mutant clones showed a higher migration ability, whereas the ABCB5 S830F mutant clone was not able to migrate from the upper side of the Boyden chamber to the lower one. (b) The migration ability of 63T ABCB5 mutant clones was also affected and was significant for the mutations S830F and S1091F. (c) The invasive ability of 17T ABCB5 WT and mutant clones was assessed, but no significant increase in invasion was observed. The P values (Student t test) are 0.4187 for Q187*, 0.5458 for S830F, 0.5856 for S1091F, and 0.8927 for the mutation S1184P. (d) The invasive ability of 63T ABCB5 WT and mutant clones was assessed, but no significant increase in invasion was observed, except for the S830F mutation. The P values (Student t test) are 0.0885 for Q187*, 0.0458 for S830F, 0.4291 for S1091F, and 0.4215 for S1184P. *P <0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. n = 3. Values are the mean ± standard error of the mean.