Skip to main content
. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2019 May 28;192:105383. doi: 10.1016/j.jsbmb.2019.105383

FIGURE 7: Allopregnanolone docking poses within the intersubunit pocket in the α1GABAAR TMD of WT and the Q242W mutant.

FIGURE 7:

(A) Representative poses from each cluster for allopregnanolone docked within the intersubunit site in WT. The receptor snapshot corresponding to each pose is shown along with the Gln242 side chain for each subunit. Green indicates clusters where the A ring points extracellular, and white indicates clusters where the A-ring points intracellular. (B) Same as (A) for the Q242W mutant.