Abstinence-induced change in neural cue reactivity predicts 7-day quit status. A, The whole-brain analysis of the abstinent>smoking satiety session revealed significant activation (red) in the anterior cingulate cortex (P ≤ 0.05, corrected). A mask (yellow) was generated using cluster correction procedures (Z ≥ 2.3, P ≤ 0.01) for percent signal change extraction. B, Participants who showed a greater increase in ACC percent signal change during abstinence (vs satiety) were more likely to relapse (OR = 2.10 per standard deviation increase in percent signal change, 95% CI: 1.05 to 4.20, P = 0.036)