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. 2019 Aug 2;98(31):e16717. doi: 10.1097/MD.0000000000016717

Figure 1.

Figure 1

The multivariate statistical analysis of serum profiling data generated in positive ion mode. (A) Plots of the principal component analysis (PCA) scores of peaks detected in the positive ion mode. 1: healthy control; 2: DILI; 3: quality control. (B) Scatter plots of the partial least squares-discriminant analysis (PLS-DA) with a positive ion model of serum obtained from patients with DILI and healthy controls. 1: healthy control; 2: DILI. (C) Validation plot of the original PLS-DA with a positive ion model, strongly indicating that the original model was valid and revealed no signs of overfitting. The permutation test was repeated for 200 times in the cross-validation plot. (D) The plots of PCA scores of the peaks detected in the positive ion mode using serum samples obtained from patients in the mild and severe injury groups. 1: healthy control; 2: mild DILI; 3: severe DILI.