Figure 1.

Expressions of C8orf4 and β-catenin in normal cervical epithelia, squamous intraepithelial lesions, and cervical squamous cell carcinomas. The expression of C8orf4 was weak in normal cervical epithelia (A) and low-grade squamous intraepithelial lesion (C), but significantly strong in high-grade squamous intraepithelial lesions (E) and cervical squamous cell carcinomas (G). The expression of β-catenin was primarily at the membrane of cells in normal cervical epithelia (B) and low-grade squamous intraepithelial lesion (D), the cytoplasmic expression of β-catenin was weak. But, in high-grade squamous intraepithelial lesion (F) and cervical squamous cell carcinoma (H), the expression of β-catenin was significantly strong in the cytoplasm. (Original magnification, 100×; streptavidin–peroxidase immunohistochemistry method). C8orf4 = chromosome 8 open reading frame 4.