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. 2019 Aug 8;6(4):ENEURO.0035-19.2019. doi: 10.1523/ENEURO.0035-19.2019

Figure 6.

Figure 6.

Motor coordination deficits in A2AR-Gpr88 mice and motor skill learning deficits in D1R-Gpr88 KO mice. Mice where tested on a rotating rod for four daily trials lasting 6 d. Overall (left panel), CMV-Gpr88 (A), D1R-Gpr88 (B), and A2AR-Gpr88 (C) mice show decreased latency to fall form the rod. When selectively analyzing the first and last training session (right panel), we observe that CMV-Gpr88 and A2AR-Gpr88 mice presented motor coordination deficits as soon as the first session which is not present in D1R-Gpr88. In the last session, however, CMV-Gpr88 and D1R-Gpr88 both present a significantly decreased time on the rod when compared to control mice, whereas A2AR-Gpr88 mice present no significant difference in the time spent on the rod when compared to their littermates. Data are represented as mean ± SEM. A, n = 21 CMV-CTL; n = 21 CMV-Gpr88. B, N = 13 D1R-CTL, N = 12 D1R-Gpr88. C, n = 17 A2AR-CTL; n = 10 A2AR-Gpr88. Open stars: one star p < 0.05; two stars p < 0.01; three stars p < 0.001 (RM two-way ANOVA). Text stars: three stars p < 0.001; one star p < 0.05 (Sidak’s multiple comparison).