Figure 5.
Suppression of dHC modestly reduces response accuracy. Light was delivered to dHC to suppress excitatory activity on 20% of trials through stage 4. A, Suppression reduced accuracy across stages compared with non-suppressed trials (Friedman’s, df = 1, χ2 = 4.8, p = 0.03). Neither response bias (B) nor RT (C) changed significantly with suppression. Analyses for each stage included 4 d of training. Stage 1 included the first 4 d of training. Stage 2 included the first 4 d following performance of 65% correct responses in a 50-trial block. Stage 3 included the first 4 d following performance of 85% correct responses in a 50-trial block. Following stage 3, correction trials were reduced gradually to 0%, at which point mice received an additional 4 d of overtraining (stage 4).