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The expression levels of serum BDNF level and hippocampal volume in subjects who harbor APOE ε4. (A) The expression levels of serum BDNF level at baseline. (B) The hippocampal volume at baseline. The data are shown as the means (±SD). ∗P < .05, ∗∗P < .01. AD = Alzheimer disease, APOE = apolipoprotein E, BDNF = brain-derived neurotrophic factor, MCI-MCI patients = patients maintaining an amnestic mild cognitive impairment (aMCI) diagnosis after 2 years.
