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. 2019 Aug 7;17:1151–1161. doi: 10.1016/j.csbj.2019.07.021

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Summary of changes that occur in the liver sinusoidal endothelial cell with aging. (a) loss of fenestrations and (b) pathways promoting ROS and cellular senescence in aging LSECs. Abbreviations: AMPK: 5′ adenosine monophosphate-activated protein kinase; BM: bone marrow; cGMP: cyclic guanosine monophosphate; EPC: endothelial progenitor cell; HGF: hepatocyte growth factor; ICAM-1: intercellular adhesion molecule 1; Id1: inhibitor of differentiation/DNA binding protein 1; IL-6: interleukin 6; NAD: nicotinamide adenine dinucleotide; NO: nitric oxide; ROS: reactive oxygen species; SIRT1: sirtuin 1; VEGF: vascular endothelial growth factor; WF: von Willebrand factor.