Table 2.

Simulated and observed drug–drug interactions with duloxetine

Substrate	Substrate dose	Duloxetine dose	Simulated AUCRa	Observed AUCR	R pred/obs	Reference study
Tolterodine	2 mg/12 hours, 9 doses	40 mg/12 hours, 9 doses	2.85 (2.59–2.94)	1.71 (1.31–2.23)a	1.67	Ref. 16
Desipramine	50 mg SD at day 6	30 mg/12 hours, 20 doses	1.75 (1.62–1.78)	2.22 (1.95–2.51)b	0.79	Ref. 15
Metoprolol	100 mg SD at day 17	30 mg day 1 then 60 mg days 2–18	1.75 (1.66–1.82)	2.80 ± 0.31c	0.63	Ref. 19

AUCR, ratio of the substrate area under the concentration‐time curve in the presence and absence of the inhibitor; R _pred/obs, ratio of model‐predicted mean exposure change of substrate to observed value; SD, single dose.

^aGeometric mean with 95% confidence interval.

^bGeometric mean with 90% confidence interval.

^cArithmetic mean ± standard deviation.