. 2019 Aug 23;63(9):e00865-19. doi: 10.1128/AAC.00865-19

TABLE 1.

GM and MIC/MEC values and ranges for tested antifungals^a and Aspergillus complex strains (n ≥ 10), as determined by the EUCAST broth microdilution method

Aspergillus complex (no. of strains tested)	MIC parameter	Value (mg/liter) for:
Aspergillus complex (no. of strains tested)	MIC parameter	AMB	ITC	VRC	POS	ISA	TRB	CAS	MFG	AFG
A. fumigatus complex (158)	GM	0.633	0.663	0.726	0.139	1.124	3.431	0.312	0.016	0.024
	MIC₅₀/MEC₅₀	0.5	0.5	0.5	0.12	1	4	0.25	0.015	0.03
	MIC₉₀/MEC₉₀	8	4	4	0.5	4	8	0.5	0.03	0.06
	Range	0.12–32	0.015–16	0.06–16	0.015–4	0.25–16	0.25–32	0.03–4	0.004–4	0.007–8
A. terreus complex (59)	GM	1.638	0.282	1.036	0.098	1.084	0.315	0.358	0.017	0.025
	MIC₅₀/MEC₅₀	2	0.25	1	0.12	1	0.25	0.5	0.015	0.03
	MIC₉₀/MEC₉₀	8	0.5	2	0.25	2	0.5	1	0.06	0.06
	Range	0.25–16	0.03–16	0.25–16	0.015–1	0.25–8	0.06–1	0.03–2	0.004–4	0.007–8
A. flavus complex (35)	GM	1.400	0.541	0.837	0.193	1.224	0.157	0.517	0.068	0.065
	MIC₅₀/MEC₅₀	1	0.5	1	0.25	1	0.12	0.25	0.03	0.03
	MIC₉₀/MEC₉₀	4	1	1	0.5	2	2	32	4	8
	Range	0.5–32	0.12–16	0.25–16	0.03–2	0.5–16	0.03–4	0.06–32	0.015–4	0.007–8
A. nidulans complex (15)	GM	2.639	0.522	0.396	0.154	0.500	0.412	0.497	0.043	0.057
	MIC₅₀/MEC₅₀	2	0.5	0.25	0.12	0.25	0.25	0.25	0.06	0.06
	MIC₉₀/MEC₉₀	16	1	1	0.5	1	2	4	0.5	0.5
	Range	0.5–16	0.12–4	0.12–1	0.03–1	0.25–8	0.06–2	0.03–8	0.004–2	0.007–4
All (273)	GM	0.916	0.534	0.773	0.138	1.082	1.139	0.349	0.021	0.029
	MIC₅₀/MEC₅₀	0.5	0.5	0.5	0.12	1	2	0.25	0.015	0.03
	MIC₉₀/MEC₉₀	8	2	2	0.5	4	8	1	0.06	0.06
	Range	0.06–32	0.015–16	0.06–16	0.015–4	0.25–16	0.03–32	0.015–32	0.004–4	0.007–8

MIC values for amphotericin B (AMB), itraconazole (ITC), voriconazole (VRC), posaconazole (POS), isavuconazole (ISA), and terbinafine (TRB), and MEC values for caspofungin (CAS), micafungin (MFG), and anidulafungin (AFG).