TABLE 3.
Transposon mutant MICs
| Strain | Disrupted locus | Common name of disrupted gene | MIC (μg/ml) |
Fold increase over transposon control | Significance of MIC difference relative to transposon control (P value) | |
|---|---|---|---|---|---|---|
| Average | SEM | |||||
| MPAO1 (parental strain) | 1.31 | 0.13 | 0.96 | 7.85 × 10−1 | ||
| PW3303 (transposon control) | PA1274 | 1.36 | 0.15 | |||
| PW5294 | PA2557 | 4.00 | 0.00 | 2.93 | 8.66 × 10−9 | |
| PW5293 | PA2557 | 3.33 | 0.42 | 2.44 | 4.04 × 10−3 | |
| PW5085 | PA2426 | pvdS | 4.00 | 0.00 | 2.93 | 8.66 × 10−9 |
| PW2543 | PA0847 | 3.80 | 0.55 | 2.79 | 1.58 × 10−3 | |
| PW2544 | PA0847 | 4.00 | 0.00 | 2.93 | 8.66 × 10−9 | |
| PW8212 | PA4282 | sbcC | 3.82 | 0.18 | 2.80 | 2.42 × 10−9 |
| PW8213 | PA4282 | sbcC | 2.00 | 0.00 | 1.47 | 1.88 × 10−3 |
| PW5076 | PA2420 | opdJ | 4.00 | 0.00 | 2.93 | 8.66 × 10−9 |
| PW8445 | PA4418 | ftsI | 3.14 | 0.40 | 2.30 | 3.60 × 10−3 |
| PW4274 | PA1866 | 4.00 | 0.47 | 2.93 | 1.64 × 10−4 | |
| PW4275 | PA1866 | 4.36 | 0.36 | 3.20 | 3.20 × 10−6 | |
| PW5165 | PA2480 | 3.43 | 0.37 | 2.51 | 8.23 × 10−4 | |
| PW5164 | PA2480 | 4.00 | 0.00 | 2.93 | 8.66 × 10−9 | |
| PW2742 | PA0958 | oprD | 4.00 | 0.00 | 2.93 | 8.66 × 10−9 |
| PW4165 | PA1798 | parS | 4.00 | 0.47 | 2.93 | 1.64 × 10−4 |
| PW4164 | PA1798 | parS | 8.00 | 0.00 | 5.87 | 9.62 × 10−13 |
| PW7954 | PA4110 | ampC | 3.14 | 0.40 | 2.30 | 3.60 × 10−3 |
| PW7953 | PA4110 | ampC | 4.00 | 0.00 | 2.93 | 8.66 × 10−9 |
| PW1778 | PA0425 | mexA | ≤0.25 | 0.00 | 0.18 | 2.54 × 10−5 |
| PW1779 | PA0425 | mexA | ≤0.25 | 0.00 | 0.18 | 2.54 × 10−5 |
| PW8689 | PA4569 | ispB | 2.00 | 0.00 | 1.47 | 1.88 × 10−3 |
| PW8881 | PA4681 | 4.33 | 0.80 | 3.18 | 1.33 × 10−2 | |
| PW8880 | PA4681 | 4.00 | 0.00 | 2.93 | 8.66 × 10−9 | |