TABLE 1.
Plasma total drug pharmacokinetic parameters of ceftolozane-tazobactam on day 6 after intravenous administration of ceftolozane-tazobactam at 40, 80 and 160 mg/kg every 8 h to healthy New Zealand White rabbitsa
| Drug and dosage (mg/kg) | AUC(0–8) (μg · h/ml) | Cmax (μg/ml) | CL (ml/h/kg) | V (ml/kg) |
|---|---|---|---|---|
| Ceftolozane | ||||
| 26b | 155.87 ± 15.02 | 137.56 ± 20.02 | 162.23 ± 17.22 | 173.64 ± 17.53 |
| 53 | 375.83 ± 23.84 | 325.96 ± 27.62 | 142.13 ± 9.01 | 161.18 ± 6.29 |
| 106 | 494.06 ± 14.00 | 356.74 ± 27.04 | 212.29 ± 5.51 | 216.58 ± 10.47 |
| Tazobactam | ||||
| 13b | 15.50 ± 4.73 | 20.77 ± 8.16 | 1,199.18 ± 487.82 | 248.35 ± 65.07 |
| 26 | 30.09 ± 4.82 | 47.84 ± 9.28 | 929.57 ± 127.33 | 154.14 ± 16.65 |
| 53 | 25.18 ± 6.81 | 33.67 ± 9.62 | 2613.92 ± 747.69 | 638.25 ± 167.30 |
a
CL, clearance; V, volume of distribution. Values are means ± SEMs.
b
Ceftolozane-tazobactam at 40 mg/kg = 26.3 mg/kg ceftolozane and 13.6 mg/kg tazobactam.