FIG 3.

Antileishmanial efficacy of oral DNDI-0690 (50 mg/kg once daily for 10 days) in an Old World CL model (L. major Friedlin REH infection of BALB/c mice). (A) The parasite load, as indicated by in vivo imaging of bioluminescent parasites in the infected rump skin over time. (B) The bioluminescence signal on day 10 (24 h after the last drug dose administration). (C) The parasite load on day 10 was confirmed using qPCR. QD, once daily; QAD, once every 2 days; po, oral drug administration; iv, intravenous drug administration. *, P > 0.05.