TABLE 1.
Disposition of topically applied DNDI-0690 in the skin of L. major-infected BALB/c mice using Franz diffusion cells
| DNDI-0690 localization | Avg % recovered (±SD)a
|
P valueb | |
|---|---|---|---|
| Uninfected skin | Infected skin | ||
| On skin (DNDI-0690 in wash and cotton swab) | 99.63 (±0.39) | 99.77 (±0.19) | 0.49 |
| In skin (DNDI-0690 extracted from skin homogenate) | 0.34 (±0.39) | 0.07 (±0.07) | 0.16 |
| Through skin (DNDI-0690 in receptor fluid) | 0.03 (±0.05) | 0.15 (±0.15) | 0.227 |
a
The total amount of DNDI-0690 per Franz diffusion cell recovered at the end of the experiment was considered 100%. The amounts of DNDI-0690 recovered from the different sites were expressed as a fraction of this amount. The average (±SD) percent for 5 infected mice and 4 uninfected mice is shown.
b
P values were determined by a t test.