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Graphical representations allowing the validation of the population pharmacokinetic model. (A and B) Observed concentrations plotted against population (A) or individual (B) predicted concentrations (milligrams per liter) (R2 = 0.684 and 0.947, respectively). (C) Weighted residuals plotted against individual predicted concentrations (milligrams per liter). (D) Weighted residuals plotted against time postadministration (hours).
