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Plot of the mean pIC50 values (n = 2) of 180 hit compounds obtained using the primary T. cruzi proteasome chymotrypsin-like activity assay and the secondary counterscreen assay. The red circles represent 39 compounds that were active against the former assay (pIC50 ≥ 4) and inactive against the counterscreen assay (pIC50 < 4). Primary assay mean Z factor = 0.67 ± 0.05 (SD), n = 12; counterscreen assay mean Z factor = 0.77 ± 0.04 (SD), n = 12.
