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. 2019 Aug 23;63(9):e00756-19. doi: 10.1128/AAC.00756-19

TABLE 1.

Bacterial isolates evaluated in this studya

Isolate Carbapenemase Specimen
source		 MHA
MIC value
(μg/ml)		 MHA
MIC value
interpretatione 		BHI+ agar
MIC value
(μg/ml)		 BHI+ agar
MIC value
interpretationf
E. cloacae complex ARB0008b NA NA 1 SUS 1.5 NA
E. cloacae complex ATCC 13047 NA NA 0.064 SUS 0.094 NA
E. cloacae complex WCM0001 NA Blood 0.023 SUS 0.023 NA
E. coli WCM0001 NA Urine 0.016 SUS 0.016 NA
E. coli TUV93-0 NA NA 0.023 SUS 0.023 NA
K. aerogenes ARB0007 NA NA 0.064 SUS 0.047 NA
K. aerogenes WCM0001 NA Respiratory/sinus 0.032 SUS 0.032 NA
K. pneumoniae WCM0001 NA Blood 0.047 SUS 0.032 NA
K. pneumoniae WCM0002 NA Respiratory/sinus 0.032 SUS 0.064 NA
P. aeruginosa PA14 NA NA 0.25 SUS 0.25 NA
V. cholerae N16961 NA NA 0.125 SUS 0.125 NA
E. cloacae complex 41952 KPC NA >32 RES >32 NA
E. coli 52862 KPC NA >32 RES 32 NA
K. aerogenes 28944 KPC NA >32 RES >32 NA
K. pneumoniae ARB0120c KPC NA 16 RES 16 NA
P. aeruginosa ARB0090d KPC NA >32 RES >32 NA
a

ARB, Centers for Disease Control and Prevention and U.S. Food and Drug Administration Antibiotic Resistance Isolate Bank; ATCC, American Type Culture Collection; BHI+, brain heart infusion agar with supplements; MHA, Mueller-Hinton agar; NA, not applicable; RES, resistant; SUS, susceptible; WCM, Weill Cornell Medicine.

b

For ARB0008, the meropenem MIC value determined by the ARB is 2 μg/ml (intermediate). The MIC value obtained using gradient diffusion on BHI+ agar is consistent with an interpretation of intermediate resistance.

c

For ARB0120, the meropenem MIC value determined by the ARB is >8 μg/ml (resistant).

d

For ARB0090, the meropenem MIC value determined by the ARB is >8 μg/ml (resistant).

e

Data were interpreted using the Clinical and Laboratories Standards Institute M100 and M45 documents.

f

There are no interpretative criteria for antibiotic susceptibility testing performed on BHI+ agar. Nonetheless, the essential agreement (where MIC values are ±1 doubling dilution) between the results of testing performed on MHA and BHI+ agar was 100% for all non-carbapenemase-producing isolates.