TABLE 1.

MICs of cefiderocol, cefepime, and meropenem against the tested strains

Organism	Type of carbapenemase	Infection model applied in this study	MIC (μg/ml)
			Cefiderocol		Cefepime	Meropenem
			ID-CAMHB	CAMHB
E. coli
ATCC 25922	—d	Thigh	0.125	0.25	0.125	≤ 0.031
AB	NDM-4	Lung	4	8	>32	32
IR-5	NDM-1	Lung	4	4	>32	>32
K. pneumoniae
ATCC 13883	—	Thigh	0.25	0.5	0.063	≤ 0.031
1478266	—	Thigh	0.5	1	0.063	0.063
1478677	—	Thigh	0.25	0.25	>32	0.125
VA-357a	KPC-2	Thigh, lung	2	8	>32	32
VA-361a	KPC-2	Lung	4	16	>32	16
VA-384a	KPC-2	Thigh, lung	4	16	>32	>32
VA-391a	KPC-3	Thigh, lung	4	16	>32	16
6560-MARb	NDM-1	Thigh, lung	2	2	>32	32
KI2c	NDM-1	Thigh, lung	8	32	>32	>32
NCTC 13443	NDM-1c	Thigh, lung	16	256	>32	>32
P. aeruginosa
SR27016	—	Thigh	0.25	0.25	1	0.5
ATCC 27853	—	Thigh, lung	0.5	2	2	0.25
SR27001	IMP-1	Thigh, lung	2	32	>32	>32
NCTC 13437	VIM-10	Lung	1	8	>32	>32
A. baumannii
BEN ST BRI	OXA-24	Lung	0.25	2	>32	>32
1485247	—	Lung	2	32	>32	8
NCTC 13301	OXA-23	Lung	1	32	>32	32
S. maltophilia
1146824	Not tested	Lung	0.125	0.125	>32	>32
1371071	Not tested	Lung	0.125	0.125	>32	>32
1392567	Not tested	Lung	0.25	0.25	>32	>32
1444463	Not tested	Lung	0.25	0.125	>32	>32

^aST258.

^bST15.

^cST14.

^d—, not detected.