TABLE 1.
Synergy of antimicrobials with colistina
| Drug | MIC (μg/ml) | FICI-MINb | Drug concn at FICI-MIN (drug/colistin)c |
|---|---|---|---|
| Doxycycline | >64 | 0.094 | 8/0.5, 4/1 |
| Minocycline | 64 | 0.063 | 2/0.5 |
| Tigecycline | 8 | 0.125 | 0.5/1 |
| Eravacycline | 4 | 0.125 | 0.25/1 |
| Clindamycin | >32 | 0.188 | 8/0.5, 4/1 |
| Fusidic acid | >32 | 0.094 | 2/1 |
| Linezolid | >64 | 0.313 | 32/1 |
| Chloramphenicol | 64 | 0.063 | 2/0.5 |
| Azithromycin | >64 | 0.063 | 4/0.5 |
| Levofloxacin | 4 | 0.250 | 0.5/1 |
| Trimethoprim-sulfamethoxazole | 4-76 | 0.156 | 0.5-9.5/0.5 |
| Rifampin | 32 | 0.063 | 1/0.25 |
| Meropenem | 32 | 0.501 | NA |
| Ceftazidime-avibactam | >64-4 | 0.125 | 0.03-4/2 |
| Amikacin | >128 | 0.504 | NA |
| Apramycin | 2 | 0.516 | NA |
| Spectinomycin | 8 | 0.531 | NA |
| Vancomycin | >64 | 0.625 | NA |
a
Colistin MIC, 16 μg/ml.
b
FICI-MIN, minimum fractional inhibitory concentration index. Synergistic results are in bold.
c
Values separated by a comma indicate two different concentration combinations that inhibited growth at the FICI-MIN. NA, combination not synergistic.