TABLE 1.
MICs of imipenem-relebactam, amikacin, colistin, and comparator agents against 10 P. aeruginosa isolates
| Isolatea | MIC (μg/ml) forb
: |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AMK | ATM | CAZ | CIP | CST | FEP | IPM | I/R | MEM | TZP | TOB | |
| CAIRD M9-44 | 4 | 8 | 2 | 0.25 | 0.5 | 2 | 1 | 1/4 | 0.5 | 4 | 1 |
| CAIRD M8-29 | 8 | 32 | 32 | >16 | 1 | 16 | 4 | 1/4 | 8 | 64 | 1 |
| CDC0508c | 8 | 8 | 16 | >16 | 1 | 16 | 16 | 2/4 | 8 | 64 | 1 |
| CAIRD M3-1 | 128 | 16 | 4 | >16 | 0.5 | 16 | 16 | 2/4 | 8 | 256 | >64 |
| CAIRD M6-6 | 16 | 16 | 32 | >16 | 1 | 16 | 16 | 4/4 | 64 | 16 | 128 |
| CAIRD M23-3 | 32 | 8 | 64 | >16 | 1 | 32 | 32 | 4/4 | 16 | 256 | 128 |
| CAIRD M1-13 | 64 | >64 | >64 | >16 | 1 | >64 | 32 | 4/4 | 32 | 64 | >64 |
| CAIRD M3-34 | 128 | 16 | 8 | >16 | 1 | 16 | 16 | 4/4 | 16 | 256 | >64 |
| CDC0526d | 32 | >64 | >64 | 4 | 0.5 | 64 | 16 | 8/4 | 32 | 32 | >64 |
| CAIRD M1-4 | 32 | 64 | 8 | >16 | 0.5 | 64 | 32 | 8/4 | >64 | 128 | 2 |
a
Unless noted otherwise, all isolates are clinical respiratory or blood P. aeruginosa isolates collected from the U.S. hospital surveillance study (46).
b
AMK, amikacin; ATM, aztreonam; CAZ, ceftazidime; CIP, ciprofloxacin; CST, colistin; FEP, cefepime; IPM, imipenem; I/R, imipenem-relebactam; MEM, meropenem; TZP, piperacillin-tazobactam; TOB, tobramycin.
c
Obtained from the FDA-CDC Antimicrobial Resistance Isolate Bank (Atlanta, GA). Isolate CDC0508 has chromosomally encoded blaPDC-35 and blaPER-1 β-lactamases.
d
Obtained from the FDA-CDC Antimicrobial Resistance Isolate Bank. Isolate CDC0526 has a chromosomally encoded blaPDC-19 β-lactamase.