Table 1.

Data of Selected Compounds for the Inhibition of H. pylori MTAN and IC₉₀ values for H. pylori Growth on Blood Agar

	H. pylori MTAN inhibition (nM)
compd	Ki	Ki*	inhibition of H. pylori growth IC90 (ng/mL)
1	0.16 ± 0.07a	0.04 ± 0.02a	80
2	0.19 ± 0.03	0.089 ± 0.019	6−12
3	0.79 ± 0.04	0.036 ± 0.002	6−8
4	0.79 ± 0.15	0.021 ± 0.004	16
11	0.058 ± 0.014	0.007 ± 0.002	10
12	0.27 ± 0.04	0.04 ± 0.01	16
13	0.78 ± 0.15	0.17 ± 0.01	7−14
15	0.56 ± 0.27	0.045 ± 0.004	18−35
19	0.17 ± 0.06	0.053 ± 0.007	16
20	0.43 ± 0.12	0.04 ± 0.01	40
22	0.34 ± 0.07	0.11 ± 0.04	9
23	0.96 ± 0.16	0.015 ± 0.004	35−70
24	0.21 ± 0.03	0.005 ± 0.002	4−8
25	0.5 ± 0.2	0.09 ± 0.02	4−8
26	0.32 ± 0.07	0.041 ± 0.002	40
27	0.16 ± 0.02	0.04 ± 0.01	>80
32	0.043 ± 0.001	0.006 ± 0.001	8
33	0.24 ± 0.07	0.016 ± 0.005	20
44	0.10 ± 0.01	N/Ob	8
53	0.10 ± 0.01	N/Ob	8
54	0.030 ± 0.003	N/Ob	8

^aThese errors were calculated based on the K_m errors, to provide an upper limit to the errors to K_i based on the data from all other inhibitor determination.

^bNo slow onset inhibition was observed.