Table 2.
Multivariable regression models showing independent associations between body mass index, sarcopenia and overall survival in head and neck cancer patients
| BMI cohort* | Sarcopenia subcohort* | |||||
|---|---|---|---|---|---|---|
| Clinical variables | HR | 95%CI | p-value | HR | 95%CI | p-value |
| Pre-treatment BMI | ||||||
| Normal-weight | 1.0 | Ref | 1.0 | Ref | ||
| Overweight | 0.44 | 0.3–0.6 | 0.000 | 0.89 | 0.5–1.5 | 0.673 |
| Sarcopenia | ||||||
| No | ||||||
| Yes | 2.08 | 1.1–3.9 | 0.021 | |||
| Age at diagnosis | ||||||
| ≤60 years | ||||||
| >60 years | 1.20 | 0.8–1.7 | 0.330 | 0.87 | 0.5–1.4 | 0.601 |
| Gender | ||||||
| Female | ||||||
| Male | 1.34 | 0.9–2.0 | 0.179 | 1.02 | 0.5–1.9 | 0.954 |
| Tumor stage | ||||||
| I/II | ||||||
| III/IV | 2.65 | 1.5–4.5 | 0.000 | 2.05 | 1.0–4.3 | 0.059 |
| Primary Treatment | ||||||
| Surgery+ | ||||||
| Chemo/Radiotherapy | 1.65 | 1.1–2.4 | 0.009 | 1.51 | 0.9–2.5 | 0.099 |
*
Body mass index (BMI). Hazard ratio (HR) and 95% confidence intervals (CI) by multivariable Cox proportional hazards regression for overall survival mutually adjusting for all variables in table. P-value for HR estimates derived by two-sided Wald test.