Table 2.
Patient response and toxicity.
| Patient no. | Disease status at study entry | Conditioning regimen before T cell infusion | No. of CAR-positive T cells infused (106/kg) | Response | CRS grade | Grade 3 toxicities (excluding CRS) | |
|---|---|---|---|---|---|---|---|
| Type | Duration | ||||||
| 1 | PD | FC | 8 | PR | 5 | 1 | None |
| 2 | PD | FC | 10 | PR | 5 | 2 | None |
| 3 | PD | FC | 5 | PR | 6 | 2 | Febrile neutropenia, anemia, neutropenia, thrombocytopenia |
| 4 | PD | FC | 11 | NR | / | None | None |
| 5 | PD | FC | 6 | CR | 14+ | 1 | None |
| 6 | PD | FC | 11 | CR | 13+ | None | None |
| 7 | PD | FC | 8 | CR | 9 | 2 | Gamma glutamyl transpeptidase level increased, febrile neutropenia, anemia, neutropenia, thrombocytopenia |
| 8 | PD | FC | 8 | CR | 6+ | 1 | None |
| 9 | PD | FC | 11 | PR | 1 | 2 | Gamma glutamyl transpeptidase level increased |
| 10 | PD | FC | 6 | CR | 1 | 2 | Heart failure, thrombocytopenia |
| 11 | PD | FC | 5 | NR | / | 2 | Febrile neutropenia, neutropenia |