Table 1.

Biological information regarding down-regulated circRNAs in Hcy-treated versus untreated ARPE-19 cells.

CircRNA ID	Fold change	FDR	p Value	circRNA type	Chr	Best transcript	Gene symbol
has_circRNA_102686	2.86	0.9	0.02	Exonic	chr2	NM_016441	CRIM1
has_circRNA_087856	4.59	1.00	0.04	Exonic	chr9	NM_002874	RAD23B
has_circRNA_404514	3.63	1.00	0.44	Exonic	chr1	NM_024646	ZYG11B
has_circRNA_104851	2.47	0.92	0.02	Exonic	chr9	NM_002874	RAD23B
has_circRNA_104852	3.08	1.00	0.07	Exonic	chr9	NM_002874	RAD23B
has_circRNA_104700	2.22	1.00	0.04	Exonic	chr8	NM_005607	PTK2
hsa_circRNA_077755	2.32	1.00	0.09	Exonic	chr6	uc003pyr.3	GJA1
hsa_circRNA_063089	2.01	1.00	0.06	Exonic	chr22	NM_002473	MYH9
hsa_circRNA_104854	4.34	1.00	0.03	Exonic	chr9	NM_002874	RAD23B
hsa_circRNA_013055	2.58	1.00	0.04	Exonic	chr1	NM_005274	GNG5
hsa_circRNA_002178	2.40	0.92	0.02	Sense overlapping	chr14	NR_002312	RPPH1
hsa_circRNA_001846	2.53	1.00	0.03	Sense overlapping	chr14	NR_002312	RPPH1
hsa_circRNA_102688	2.45	0.88	0.01	Exonic	chr2	NM_016441	CRIM1
hsa_circRNA_102403	2.21	0.76	0.01	Exonic	chr19	NM_018959	DAZAP1
hsa_circRNA_101828	2.39	1.00	0.05	Exonic	chr16	NM_025187	C16orf70
hsa_circRNA_102402	2.70	0.53	0.00	Exonic	chr19	NM_018959	DAZAP1
hsa_circRNA_103670	2.08	1.00	0.41	Exonic	chr4	NM_144571	CNOT6L

CircRNA types: Different classes of circRNAs as: “exonic”, “intronic”, and sense overlapping. P value: p value calculated from paired t-test. FDR: FDR is calculated from Benjamini Hochberg FDR. Fold Change: The absolute ratio (no log scale) of normalized intensities between two conditions. Chr: chromosome; Best transcript, is transcribed from the same gene position with circular RNA, the sequence information is most similar to circular RNA. Expression values for circRNAs that are known to be down-regulated more than three folds indicated in bold.