Table 3.

Endoscopy based disease activity indices in inflammatory bowel disease^{12, 13, 50, 99}

Index	Scoring	Agreement among readers	Comments
Ulcerative Colitis
Mayo score	Step-wise 4 grade scale based on vascular pattern, erythema, friability, erosions, ulcerations and bleeding	Interobserver: Kappa 0.38 95% CI 0.33 – 0.43	Ease of administration Widely used Not validated
UCEIS	Numeric grading of sub-scores for vascular pattern, bleeding, and erosions/ulcerations	Interobserver: Kappa 0.50 95% CI 0.49 – 0.52	New index Not widely used Partially validated
Crohn’s Disease
CDEIS	Numerical grading (0–44 points) based on variables related to ulcerations, area of involvement, and stenosis characteristics in colon and TI	Intraobserver: ICC 0.89 95% CI 0.86 – 0.93 Interobserver: ICC 0.71 95% CI 0.61 – 0.79	Detailed assessment, accounts for global disease (concerns regarding feasibility of use in practice) Partially validated poor agreement for ulcers
SES-CD	Numerical grading (0–56 points) based on variables related to size of ulcer, degree of ulcerated surface, affected surface, or presence of narrowing throughout the colon/TI	Intraobserver: ICC 0.91 95% CI 0.87 – 0.94 Interobserver: ICC 0.83 95% CI, 0.75 – 0.89	Simplified version of CDEIS Partially validated High degree of correlation with CDEIS for grading and responsiveness to changes

Kappa values categorized as: poor (< 0.2); fair (0.21 – 0.4); moderate (0.41 – 0.6); good (0.61 – 0.8), and very good agreement (0.81 – 1.0). Concordance correlation coefficient (CCC) categorized as: excellent (0.81–1.00), good (0.61–0.80), moderate (0.41–0.60), and fair agreement (0.21–0.40). UCEIS – Ulcerative colitis endoscopic index of severity; CDEIS – Crohn’s disease endoscopic index of severity; SES-CD – Simplified endoscopic score in Crohn’s disease; TI – terminal ileum