Skip to main content
. Author manuscript; available in PMC: 2019 Aug 26.
Published in final edited form as: Cell Rep. 2019 Jul 16;28(3):625–639.e6. doi: 10.1016/j.celrep.2019.06.033

Figure 4. Y1Cre Neurons Selectively Transmit Light Touch Information.

Figure 4.

(A and B) Sensitivity to von Frey hair stimulation of the hindpaw glabrous skin is reduced following Y1Cre neuron ablation (A; control, n = 6; ablated, n = 9) or silencing (B; control, n = 8; silenced, n = 8).

(C) Glabrous skin sensitivity to von Frey hair stimulation is elevated following Y1Cre neuron activation (control, n = 6; activated, n = 6).

(D–F) Responses to dynamic touch (D; control, n = 11; ablated, n = 13), pinprick (E; control, n = 11; ablated, n = 13), and Randall-Selitto (F; control, n = 12; ablated, n = 9) are unchanged after Y1Cre neuron ablation.

(G and H) Chemical pain responses following hindpaw injection of capsaicin (G; control, n = 11; ablated, n = 9) or formalin (H; control, n = 9; ablated, n = 7) are not altered following Y1Cre neuron ablation.

(I and J) Y1Cre neuron-ablated mice show normal heat responses as assessed by the hot plate (I; control, n = 12; ablated, n = 9) and Hargreaves (J; control, n = 12; ablated, n = 9) assays.

**p < 0.01, ***p < 0.001. Data: mean ± SEM.