Table 1.
Demographic Characteristics and Lifetime Prevalences of Alcohol Dependence and Habitual Smoking in Probands and Siblings
| COGA Probands (n = 1,212) | COGA Siblings (n = 2,755) | Control Probands (n = 217) | Control Siblings (n = 254) | |
|---|---|---|---|---|
| Gender | ||||
| Men (n) | 916* | 1,197 | 111 | 111 |
| Women (n) | 296* | 1,558 | 106 | 143 |
| Age | ||||
| Mean (years) | 37.72* | 36.35** | 34.57 | 26.15 |
| Range (years) | 17–77 | 18–76 | 18–68 | 17–48 |
| Alcohol Dependence | ||||
| Men (%) | 100.0* | 49.7** | 16.2 | 19.8 |
| Women (%) | 100.0* | 23.8** | 03.8 | 06.0 |
| Habitual Smoking | ||||
| Men (%) | 63.0* | 41.6** | 18.0 | 13.5 |
| Women (%) | 55.0* | 30.4** | 12.3 | 09.8 |
*
Statistically significant difference (i.e., p < 0.001) versus control probands.
**
Statistically significant difference (i.e., p < 0.001) versus control siblings.
COGA = Collaborative Study on the Genetics of Alcoholism.
Probands = alcohol-dependent patients and control subjects initially recruited for the COGA study.
SOURCE: Adapted from Bierut et al. 1998.