Table 3.
Risk Ratio (95% Confidence Interval) | ||
---|---|---|
| ||
Alcohol Dependence | Habitual Smoking | |
Sibling Characteristics | ||
| ||
Birth Cohort | ||
Born before 1950 | 1.00 | 1.00 |
Born 1950–1959 | 1.53 (1.23–1.90) | 0.63 (0.53–0.77) |
Born 1960 or later | 2.07 (1.65–2.60) | 0.50 (0.41–0.61) |
Gender | ||
Male | 1.00 | 1.00 |
Female | 0.48 (0.42–0.55) | 0.86 (0.75–0.98) |
Alcohol Dependence | NA | 2.06 (1.78–2.39) |
Habitual Smoking | 1.92 (1.68–2.20) | NA |
Proband Characteristics | ||
| ||
Gender | ||
Male | 1.00 | 1.00 |
Female | 1.09 (0.94–1.26) | 1.09 (0.91–1.30) |
Alcohol Dependence | 2.60 (1.60–4.01) | 1.66 (0.99–2.79) |
Habitual Smoking | 0.98 (0.85–1.12) | 1.77 (1.48–2.12) |
COGA = Collaborative Study on the Genetics of Alcoholism.
Probands = alcohol-dependent patients and control subjects initially recruited for the COGA study.
SOURCE: Adapted in part from Bierut et al. 1998.