Summary of findings 2. Additional summary of findings.
| Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery | |||||
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Patient or population: patients undergoing abdominal or pelvic surgery Settings: inpatient followed by outpatient, worldwide Intervention: thromboprophylaxis with low molecular weight heparin for ≥ 14 days Comparison: thromboprophylaxis during hospitalization only | |||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | |
| Risk with only in‐hospital thrombopropylaxis | Risk with thromboprophylaxis ≥14 days | ||||
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All VTE (subgroup analysis open only) Follow‐up: 30 days postoperatively |
Study population | OR 0.42, (0.29 to 0.60) | 1503 (6 RCTs) |
⊕⊕⊕⊝ moderate1 | |
| 138 per 1000 | 58 per 1000 (40 to 83) | ||||
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All DVT (subgroup analysis open only) Follow‐up: 30 days postoperatively |
Study population | OR 0.43, (0.30 to 0.62) | 1503 (6 RCTs) |
⊕⊕⊕⊝ moderate1 | |
| 134 per 1000 | 58 per 1000 (40 to 83) | ||||
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All VTE (sensitivity analysis unpublished) Follow‐up: 30 days postoperatively |
Study population | OR 0.38, (0.27 to 0.56) | 1620 (6 RCTs) |
⊕⊕⊕⊝ moderate1 | |
| 128 per 1000 | 49 per 1000 (35 to 72) | ||||
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All DVT (sensitivity analysis unpublished) Follow‐up: 30 days postoperatively |
Study population | OR 0.40, (0.27 to 0.58) | 1620 (6 RCTs) |
⊕⊕⊕⊝ moderate1 | |
| 124 per 1000 | 50 per 1000 (33 to 72) | ||||
| *The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; OR: odds Ratio; RCT: randomized Controlled Trial; VTE: venous thromboembolism; DVT: deep venous thrombosis | |||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | |||||
1Downgraded one level for serious risk of bias (includes at least one study with overall high risk of bias)