Jørgensen 2002.
Methods | RCT, double‐blinded, venography. | |
Participants | Patients undergoing curative surgery for abdominal or pelvic cancer. | |
Interventions | LMWH (tinzaparin 3500 IU, total treatment period of 28 days) or placebo. | |
Outcomes | LMWH 58 Placebo 50 | |
Notes | Unpublished data. Presented as an abstract. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated allocation. |
Allocation concealment (selection bias) | Unclear risk | Not described in abstract. |
Blinding (performance bias and detection bias) All outcomes | Low risk | Placebo‐controlled double‐blind study. Patients, healthcare providers, data collectors, outcome assessors and data analysts were blinded. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not described in abstract. |
Incomplete outcome data (attrition bias) All outcomes | High risk | Study terminated prematurely due to lack of funding and high attrition rate (rate not reported). |
Selective reporting (reporting bias) | Unclear risk | Intention‐to‐treat analysis of patients reaching an evaluable VTE end point (venogram or objection verification of symptomatic VTE). Adequate definitions of VTE and bleeding complications were described. |
Other bias | High risk | Premature termination of trial. Full details of study unclear because Abstract only. Bilateral venography performed on day 28 to 35. |