Table 1.
Association of rs33972313 with types of cataract (1) mixed cataracts, (2) pure cataracts and (3) lens opacity scores in the two centre India age-related Eye Disease population study (INDEYE)
| Mixed cataracts*† | Any nuclear | Any cortical | Any posterior subcapsular |
| OR (95% CI)‡ | OR (95% CI)‡ | OR (95% CI)‡ | |
| Cases (n) | 2295 | 494 | 1026 |
| Case genotype (n) | 73 GA/AA, 2222 GG | 20 GA/AA, 474 GG | 37 GA/AA, 989 GG |
| AA and GA versus GG | 1.27 (0.83 to 1.95) | 2.16 (1.34 to 3.49) | 1.68 (1.06 to 2.65) |
| P effect | 0.279 | 0.002 | 0.03 |
| P difference by centre | 0.789 | 0.569 | 0.676 |
| Pure cataracts§† | Pure nuclear | Pure cortical | Pure posterior subcapsular |
| OR (95% CI)‡ | OR (95% CI)‡ | OR (95% CI)‡ | |
| Cases (n) | 1429 | 192 | 222 |
| Case genotype (n) | 41 GA/AA, 1388 GG | 9 GA/AA, 183 GG | 6 GA/AA, 216 GG |
| AA and GA versus GG | 1.11 (0.69 to 1.80) | 2.29 (1.12 to 4.65) | 1.19, (0.56 to 2.52) |
| P effect | 0.671 | 0.023 | 0.653 |
| P difference by centre | 0.672 | 0.995 | 0.712 |
| Opacity score | Nuclear score | Cortical score | Posterior subcapsular score |
| Beta (95% CI)¶ | Beta (95% CI)¶ | Beta (95% CI)¶ | |
| Participants (n) | 4318 | 4336 | 4334 |
| Participants genotype | 134 GA/AA, 4184 GG | 134 GA/AA, 4202 GG | 134 GA/AA, 4200 GG |
| AA and GA versus GG | 0.007 (−0.159 to 0.173) | 0.187 (0.005 to 0.369) | 0.103 (−0.080 to 0.286) |
| P effect | 0.932 | 0.045 | 0.264 |
| P difference by centre | 0.455 | 0.798 | 0.220 |
Any cataract type (pure or mixed) defined as Lens Opacity Classification System III grade: nuclear opacities ≥4, cortical opacities ≥3, posterior subcapsular opacities ≥2.
Comparator group (controls) without cataract or operated cataract (ie <4 for nuclear opacities and <3 for cortical opacities and <2 for posterior subcapsular cataract, no dense opacities and no aphakia/pseudophakia); n=1462, 40 GA/AA and 1422 GG.
OR and 95% CI calculated from logistic regression adjusted for age, sex, study centre.
Pure cataract type defined as Lens Opacity Classification System III grade: nuclear opacities ≥4, cortical opacities ≥3, posterior subcapsular opacities ≥2, and no other type of opacity.
Beta coefficient (Beta) and 95% CI from regression analysis adjusted for age, sex, study center.
Standardised scores of Lens Opacity Classification System III grade: nuclear opacity score in the worse eye graded in 0.1 units from 0.5 to 6.9; cortical opacity score in the worse eye graded in 0.1 units from 0 to 5.9; posterior capsular opacity score in the worse eye graded in 0.1 units from 0 to 5.9.