Table 2.
Association of rs6596473 with types of cataract (1) mixed cataracts, (2) pure cataracts and (3) lens opacity scores in the two centre India age-related Eye Disease population study (INDEYE)
| Mixed cataracts*† | Any nuclear | Any cortical | Any posterior subcapsular |
| OR (95% CI)‡ | OR (95% CI)‡ | OR (95% CI)‡ | |
| Cases (n) | 2288 | 491 | 1026 |
| Additive association | 1.05 (0.97 to 1.15) | 1.02 (0.86 to 1.22) | 1.05 (0.93 to 1.19) |
| P effect | 0.220 | 0.789 | 0.406 |
| P difference by centre | 0.826 | 0.782 | 0.918 |
| Pure cataracts§† | Pure nuclear | Pure cortical | Pure posterior subcapsular |
| OR (95% CI)‡ | OR (95% CI)‡ | OR (95% CI)‡ | |
| Cases (n) | 1421 | 187 | 218 |
| Additive association | 1.05 (0.95 to 1.17) | 0.97 (0.76 to 1.24) | 0.99 (0.78 to 1.27) |
| P effect | 0.304 | 0.825 | 0.966 |
| P difference by centre | 0.904 | 0.564 | 0.821 |
| Opacity scores¶ | Nuclear score | Cortical score | Posterior subcapsular score |
| Beta (95% CI)** | Beta (95% CI)** | Beta (95% CI)** | |
| Participants (n) | 4292 | 4310 | 4308 |
| Per allele association | 0.030 (−0.006 to 0.065) | −0.018 (−0.054 to 0.019) | 0.021 (−0.022 to 0.063) |
| P effect | 0.103 | 0.339 | 0.338 |
| P difference by centre | 0.683 | 0.181 | 0.761 |
Any cataract type (pure or mixed) defined as Lens Opacity Classification System III grade: nuclear opacities ≥4, cortical opacities ≥3, posterior subcapsular opacities ≥2.
Comparator group (controls) without cataract or operated cataract (ie <4 for nuclear opacities and <3 for cortical opacities and <2 for posterior subcapsular cataract, no dense opacities and no aphakia/pseudophakia); n=1462.
OR and 95% CI calculated from logistic regression adjusted for age, sex, study centre.
Pure cataract type defined as Lens Opacity Classification System III grade: nuclear opacities ≥4 cortical opacities ≥3, posterior subcapsular opacities ≥2 and no other type of opacity.
Standardised scores of Lens Opacity Classification System III grade: nuclear opacity score in the worse eye graded in 0.1 units from 0.5 to 6.9; cortical opacity score in the worse eye graded in 0.1 units from 0 to 5.9; posterior capsular opacity score in the worse eye graded in 0.1 units from 0 to 5.9.
Beta coefficient (Beta) and 95% CI from regression analysis adjusted for age, sex, study centre.