| Statement | Evidentiary support | Expert agreement |
| With respect to the pathogenesis of CRC, ‘the driver–passenger’ model40 accounts for key observations from mechanistic studies and investigations of the on-tumour versus off-tumour microbiome. | Weak evidence from human studies (9) | Agree (8) |
| The role of the microbiome in the aetiopathogenesis of cancer can be conceptualised as one apex of a tripartite, multidirectional interactome alongside the environment and an epigenetically/genetically vulnerable host. | Weak evidence from human studies (7) | Strongly agree (9) |
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