Table S2.
Patient’s original data in the present study
| Age | Sex | Primary site | Operation history | GEM-containing regimen | GEM containing regimen | Date of death | Antibiotics treatment | |
|---|---|---|---|---|---|---|---|---|
| Date of start | Date of discontinuation | |||||||
| 69 | Female | Pancreas | No | GC | 11-05-2017 | 31-08-2018 | 31-08-2018 | Carbapenem |
| 63 | Female | Biliary tract | No | GC | 14-11-2008 | 01-05-2009 | 29-07-2009 | Carbapenem |
| 67 | Female | Pancreas | No | GEM | 27-06-2008 | 24-09-2008 | 14-11-2008 | Carbapenem |
| 54 | Male | Biliary tract | No | GC | 05-07-2017 | 12-10-2017 | 31-08-2018 | Cephem |
| 67 | Male | Biliary tract | No | GC | 15-10-2015 | 17-12-2015 | 08-04-2017 | Cephem |
| 62 | Male | Biliary tract | No | GC | 17-10-2013 | 02-07-2015 | 20-08-2015 | Cephem |
| 69 | Male | Pancreas | No | GC | 25-07-2016 | 26-09-2016 | 23-05-2017 | Cephem |
| 75 | Female | Pancreas | No | GC | 16-06-2015 | 29-04-2016 | 24-08-2016 | Cephem |
| 25 | Male | Sarcoma | No | GD | 16-12-2013 | 25-05-2017 | 25-11-2017 | Cephem |
| 32 | Female | Sarcoma | No | GD | 30-10-2017 | 16-11-2017 | 12-01-2018 | Cephem |
| 68 | Male | Biliary tract | No | GEM | 24-11-2015 | 20-06-2017 | 31-08-2018 | Cephem |
| 57 | Male | CUP | No | GEM | 18-08-2017 | 10-11-2017 | 02-01-2018 | Cephem |
| 74 | Female | Pancreas | No | GEM | 05-04-2010 | 02-06-2010 | 04-06-2010 | Cephem |
| 76 | Female | Pancreas | No | GEM | 11-12-2006 | 10-10-2008 | 11-12-2008 | Cephem |
| 70 | Female | Pancreas | No | GEM | 24-08-2006 | 04-12-2008 | 12-01-2009 | Cephem |
| 49 | Male | Pancreas | No | GEM | 24-07-2014 | 05-12-2014 | 21-02-2015 | Cephem |
| 67 | Male | Pancreas | No | GEM | 06-02-2018 | 27-02-2018 | 29-04-2018 | Cephem |
| 66 | Male | Pancreas | No | GEM | 23-03-2017 | 24-05-2017 | 26-06-2018 | Cephem |
| 66 | Female | Pancreas | No | GEM | 11-12-2017 | 31-08-2018 | 31-08-2018 | Cephem |
| 68 | Female | Pancreas | No | GEM | 12-05-2017 | 19-07-2017 | 24-09-2017 | Cephem |
| 50 | Male | Pancreas | No | GEM | 30-09-2016 | 09-12-2016 | 23-04-2017 | Cephem |
| 72 | Male | Pancreas | No | GEM | 04-08-2016 | 15-09-2016 | 17-11-2016 | Cephem |
| 84 | Female | Biliary tract | No | GnP | 27-12-2017 | 31-08-2018 | 31-08-2018 | Cephem |
| 42 | Female | Biliary tract | No | GnP | 16-03-2016 | 12-09-2016 | 01-02-2017 | Cephem |
| 62 | Female | Biliary tract | No | GC | 31-05-2016 | 01-11-2016 | 01-11-2016 | New quinolone |
| 58 | Male | CUP | No | GC | 26-03-2010 | 18-11-2010 | 14-02-2011 | New quinolone |
| 70 | Male | Pancreas | No | GC | 31-10-2015 | 12-01-2016 | 25-03-2016 | New quinolone |
| 66 | Male | Pancreas | No | GC | 22-08-2014 | 29-01-2015 | 19-03-2015 | New quinolone |
| 68 | Female | Ulinary bladder | No | GC | 12-09-2011 | 05-12-2011 | 16-04-2012 | New quinolone |
| 36 | Male | Sarcoma | No | GD | 19-06-2015 | 07-04-2016 | 07-04-2016 | Ne w quinolone |
| 59 | Male | Biliary tract | No | GEM | 30-08-2016 | 11-04-2017 | 31-07-2017 | New quinolone |
| 61 | Male | Biliary tract | No | GEM | 04-06-2012 | 23-08-2012 | 25-10-2012 | New quinolone |
| 58 | Male | Biliary tract | No | GEM | 01-11-2012 | 31-01-2013 | 03-01-2014 | New quinolone |
| 80 | Female | Biliary tract | No | GEM | 28-02-2011 | 16-05-2011 | 21-10-2011 | New quinolone |
| 59 | Female | Biliary tract | No | GEM | 31-07-2009 | 12-11-2009 | 01-04-2011 | New quinolone |
| 78 | Male | Biliary tract | No | GEM | 18-09-2007 | 06-11-2009 | 10-05-2010 | New quinolone |
| 54 | Male | Pancreas | No | GEM | 26-03-2015 | 28-05-2015 | 16-07-2015 | New quinolone |
| 72 | Male | Pancreas | No | GEM | 13-02-2015 | 31-08-2018 | 31-08-2018 | New quinolone |
| 64 | Male | Pancreas | No | GEM | 21-02-2011 | 08-08-2011 | 29-03-2012 | New quinolone |
| 66 | Male | Pancreas | No | GEM | 24-09-2010 | 11-03-2011 | 28-05-2011 | New quinolone |
| 74 | Male | Pancreas | No | GEM | 26-05-2010 | 05-01-2011 | 03-08-2011 | New quinolone |
| 48 | Male | Pancreas | No | GEM | 06-04-2009 | 21-08-2009 | 08-05-2010 | New quinolone |
| 71 | Male | Pancreas | No | GEM | 06-09-2007 | 16-11-2007 | 18-01-2008 | New quinolone |
| 70 | Male | Pancreas | No | GEM | 26-05-2006 | 23-05-2007 | 05-02-2010 | New quinolone |
| 69 | Female | Pancreas | No | GEM | 05-10-2006 | 21-02-2007 | 23-11-2007 | New quinolone |
| 73 | Male | Biliary tract | No | GnP | 18-05-2015 | 16-07-2015 | 11-09-2015 | New quinolone |
| 77 | Male | Pancreas | No | GnP | 02-07-2015 | 26-10-2015 | 18-06-2016 | New quinolone |
| 58 | Male | Pancreas | No | GnP | 12-12-2011 | 20-01-2012 | 10-02-2012 | New quinolone |
| 87 | Female | Pancreas | No | GnP | 16-02-2018 | 23-04-2018 | 19-06-2018 | New quinolone |
| 70 | Male | Pancreas | No | GnP | 04-09-2017 | 24-05-2018 | 05-07-2018 | New quinolone |
| 80 | Male | Pancreas | No | GnP | 30-08-2017 | 18-12-2017 | 19-02-2018 | New quinolone |
| 63 | Male | Pancreas | No | GEM | 28-06-2017 | 21-08-2017 | 31-08-2018 | Penicilline |
| 66 | Male | Pancreas | No | GEM | 25-11-2014 | 01-09-2015 | 01-04-2016 | β-lactamase inhibitor |
| 61 | Female | Biliary tract | No | GC | 25-08-2014 | 18-09-2014 | 25-09-2014 | None |
| 70 | Male | Biliary tract | No | GC | 24-03-2014 | 30-05-2014 | 29-07-2014 | None |
| 78 | Female | Biliary tract | No | GC | 16-02-2016 | 13-06-2016 | 31-07-2016 | None |
| 71 | Male | Biliary tract | No | GC | 12-08-2016 | 07-10-2016 | 05-05-2017 | None |
| 68 | Female | Biliary tract | No | GC | 14-07-2014 | 07-10-2014 | 15-05-2015 | None |
| 75 | Female | Biliary tract | No | GC | 29-01-2013 | 12-09-2013 | 17-08-2014 | None |
| 58 | Male | Biliary tract | No | GC | 21-01-2013 | 21-09-2013 | 06-12-2013 | None |
| 69 | Female | Biliary tract | No | GC | 10-05-2010 | 29-06-2010 | 21-02-2011 | None |
| 79 | Female | CUP | No | GC | 31-05-2012 | 24-05-2013 | 30-09-2013 | None |
| 50 | Male | NEC | No | GC | 06-10-2014 | 20-04-2015 | 27-09-2015 | None |
| 64 | Female | Biliary tract | No | GCS | 09-10-2015 | 16-06-2016 | 06-04-2017 | None |
| 74 | Male | Biliary tract | No | GCS | 06-01-2016 | 15-07-2016 | 12-10-2016 | None |
| 32 | Male | Sarcoma | No | GD | 06-03-2017 | 21-03-2017 | 04-04-2017 | None |
| 52 | Female | Sarcoma | No | GD | 31-10-2016 | 26-12-2016 | 28-02-2017 | None |
| 70 | Male | Biliary tract | No | GEM | 10-02-2011 | 12-04-2011 | 28-06-2011 | None |
| 72 | Female | Biliary tract | No | GEM | 04-09-2008 | 28-10-2008 | 17-04-2009 | None |
| 78 | Male | CUP | No | GEM | 27-06-2017 | 25-07-2017 | 05-10-2017 | None |
| 70 | Male | CUP | No | GEM | 14-04-2008 | 18-08-2008 | 28-08-2008 | None |
| 46 | Female | Breast | No | GEM | 10-04-2008 | 22-05-2008 | 18-02-2009 | None |
| 76 | Male | Pancreas | No | GEM | 20-09-2016 | 05-01-2017 | 13-05-2017 | None |
| 29 | Male | Pancreas | No | GEM | 06-01-2014 | 28-02-2014 | 20-06-2014 | None |
| 80 | Female | Pancreas | No | GEM | 04-09-2014 | 30-10-2014 | 14-02-2015 | None |
| 42 | Male | Pancreas | No | GEM | 22-08-2013 | 15-12-2013 | 15-12-2013 | None |
| 61 | Female | Pancreas | No | GEM | 17-01-2014 | 17-09-2014 | 14-11-2014 | None |
| 65 | Male | Pancreas | No | GEM | 16-05-2013 | 08-10-2013 | 02-10-2013 | None |
| 45 | Female | Pancreas | No | GEM | 23-04-2013 | 06-06-2013 | 12-07-2013 | None |
| 61 | Male | Pancreas | No | GEM | 05-10-2012 | 06-11-2012 | 21-11-2012 | None |
| 55 | female | Pancreas | no | GEM | 19-04-2013 | 18-06-2013 | 23-09-2013 | none |
| 69 | male | Pancreas | no | GEM | 15-01-2013 | 25-06-2013 | 05-07-2014 | none |
| 63 | female | Pancreas | no | GEM | 26-04-2012 | 01-06-2012 | 01-09-2012 | none |
| 56 | male | Pancreas | no | GEM | 22-09-2011 | 31-10-2011 | 17-11-2011 | none |
| 52 | male | Pancreas | no | GEM | 13-12-2010 | 11-04-2011 | 11-04-2011 | none |
| 69 | male | Pancreas | no | GEM | 12-08-2010 | 14-10-2010 | 02-11-2010 | none |
| 62 | female | Pancreas | no | GEM | 14-01-2010 | 18-02-2010 | 15-03-2010 | none |
| 66 | female | Pancreas | no | GEM | 14-12-2009 | 08-02-2010 | 01-06-2010 | none |
| 68 | male | Pancreas | no | GEM | 06-10-2009 | 10-02-2010 | 30-11-2010 | none |
| 73 | male | Pancreas | no | GEM | 14-07-2009 | 13-08-2009 | 21-11-2009 | none |
| 69 | male | Pancreas | no | GEM | 07-07-2009 | 27-08-2009 | 17-10-2009 | none |
| 74 | female | Pancreas | no | GEM | 02-02-2009 | 23-03-2009 | 23-03-2009 | none |
| 64 | male | Pancreas | no | GEM | 27-11-2008 | 21-01-2009 | 24-02-2009 | none |
| 57 | male | Pancreas | no | GEM | 25-11-2008 | 08-06-2009 | 17-08-2009 | none |
| 63 | male | Pancreas | no | GEM | 26-09-2008 | 07-11-2008 | 11-04-2009 | none |
| 75 | female | Pancreas | no | GEM | 29-05-2008 | 17-07-2008 | 10-06-2010 | none |
| 77 | male | Pancreas | no | GEM | 21-05-2008 | 04-09-2008 | 02-06-2009 | none |
| 70 | male | Pancreas | no | GEM | 11-01-2008 | 04-03-2008 | 14-04-2008 | none |
| 44 | male | Pancreas | no | GEM | 10-10-2007 | 17-03-2008 | 23-05-2008 | none |
| 67 | male | Pancreas | no | GEM | 27-07-2007 | 14-09-2007 | 10-11-2007 | none |
| 72 | male | Pancreas | no | GEM | 02-04-2007 | 28-05-2007 | 06-08-2007 | none |
| 60 | male | Pancreas | no | GEM | 27-12-2006 | 17-08-2007 | 20-02-2008 | none |
| 57 | female | Pancreas | no | GEM | 22-11-2006 | 10-01-2007 | 24-04-2007 | none |
| 72 | female | Pancreas | no | GEM | 30-03-2006 | 13-06-2006 | 04-02-2007 | none |
| 69 | male | Pancreas | no | GEM | 10-08-2012 | 11-01-2013 | 13-04-2013 | none |
| 63 | female | Pancreas | no | GEM plus elrotinib | 16-09-2010 | 11-01-2012 | 29-02-2012 | none |
| 71 | male | Pancreas | no | GnP | 20-02-2018 | 21-08-2018 | 31-08-2018 | none |
| 70 | male | Pancreas | no | GnP | 28-11-2017 | 16-01-2018 | 27-03-2018 | none |
| 60 | male | Pancreas | no | GnP | 02-10-2017 | 26-02-2018 | 12-03-2018 | none |
| 72 | female | Pancreas | no | GnP | 08-09-2017 | 16-03-2018 | 27-05-2018 | none |
| 61 | male | Pancreas | no | GnP | 16-01-2018 | 21-02-2018 | 12-05-2018 | none |
| 68 | male | Pancreas | no | GnP | 06-09-2017 | 09-01-2018 | 26-01-2018 | none |
| 69 | female | Pancreas | no | GnP | 21-03-2017 | 27-04-2017 | 22-01-2018 | none |
| 66 | male | Pancreas | no | GnP | 22-11-2017 | 31-08-2018 | 31-08-2018 | none |
| 65 | female | Pancreas | no | GnP | 10-03-2017 | 01-05-2017 | 28-07-2017 | none |
| 65 | male | Pancreas | no | GnP | 31-01-2017 | 20-07-2017 | 08-10-2017 | none |
| 75 | male | Pancreas | no | GnP | 20-09-2016 | 31-01-2017 | 28-03-2017 | none |
| 75 | female | Pancreas | no | GnP | 26-09-2016 | 17-10-2016 | 15-11-2016 | none |
| 73 | female | Pancreas | no | GnP | 30-08-2016 | 20-12-2016 | 20-03-2017 | none |
| 81 | male | Pancreas | no | GnP | 28-07-2016 | 13-10-2016 | 18-01-2017 | none |
| 62 | male | Pancreas | no | GnP | 03-03-2017 | 06-04-2017 | 13-05-2017 | none |
| 67 | male | Pancreas | no | GnP | 22-06-2016 | 21-09-2016 | 16-12-2016 | none |
| 77 | female | Pancreas | no | GnP | 12-05-2015 | 04-08-2015 | 03-09-2015 | none |
| 74 | male | Sarcoma | yes | GD | 14-10-2015 | 29-02-2016 | 29-08-2018 | cephem |
| 38 | female | Sarcoma | yes | GD | 11-12-2014 | 17-06-2015 | 27-08-2015 | cephem |
| 51 | female | Sarcoma | yes | GD | 13-08-2015 | 22-02-2016 | 15-03-2016 | cephem |
| 58 | female | Pancreas | yes | GEM | 07-06-2017 | 04-09-2017 | 15-11-2017 | cephem |
| 75 | female | Biliary tract | yes | GnP | 27-09-2017 | 22-02-2018 | 04-08-2018 | cephem |
| 78 | male | Pancreas | yes | GnP | 30-10-2017 | 19-01-2018 | 26-09-2018 | cephem |
| 50 | male | Pancreas | yes | GnP | 03-10-2016 | 21-06-2017 | 27-03-2018 | cephem |
| 63 | female | Pancreas | yes | GnP | 23-07-2015 | 07-01-2016 | 30-06-2016 | cephem |
| 67 | female | Pancreas | yes | GnP | 18-07-2017 | 19-03-2018 | 12-04-2018 | cephem |
| 59 | female | Pancreas | yes | GnP | 29-06-2016 | 26-12-2016 | 22-01-2017 | cephem |
| 31 | male | Sarcoma | yes | GD | 19-12-2013 | 11-12-2014 | 22-06-2015 | new quinolone |
| 64 | male | Sarcoma | yes | GD | 16-04-2014 | 20-06-2014 | 25-11-2015 | new quinolone |
| 51 | male | Sarcoma | yes | GD | 10-11-2015 | 15-12-2015 | 04-10-2016 | new quinolone |
| 61 | female | Biliary tract | yes | GEM | 24-11-2016 | 27-04-2017 | 13-01-2018 | new quinolone |
| 78 | female | Pancreas | yes | GEM | 09-11-2009 | 26-04-2010 | 26-07-2010 | new quinolone |
| 66 | female | Pancreas | yes | GEM plus erlotinib | 20-06-2008 | 04-11-2008 | 09-01-2009 | new quinolone |
| 45 | Fe male | Biliary tract | Yes | GnP | 08-07-2015 | 10-06-2016 | 04-10-2016 | new Quinolone |
| 46 | Female | Pancreas | Yes | GnP | 22-03-2013 | 26-02-2015 | 31-08-2018 | New quinolone |
| 63 | Male | Pancreas | Yes | GnP | 22-08-2013 | 24-10-2013 | 06-02-2014 | New quinolone |
| 63 | Male | Pancreas | Yes | GnP | 30-01-2014 | 09-04-2014 | 21-08-2016 | New quinolone |
| 58 | Male | Pancreas | Yes | GnP | 10-08-2015 | 14-10-2015 | 14-03-2016 | New quinolone |
| 69 | Male | Pancreas | Yes | GnP | 07-06-2017 | 02-02-2018 | 31-08-2018 | New quinolone |
| 64 | FEMALE | Biliary tract | Yes | GC | 24-05-2016 | 08-02-2017 | 14-12-2017 | None |
| 62 | Male | Biliary tract | Yes | GC | 25-08-2015 | 12-04-2016 | 01-01-2017 | None |
| 36 | Male | Biliary tract | Yes | GCS | 21-07-2006 | 24-03-2008 | 21-05-2009 | None |
| 75 | Male | Sarcoma | Yes | GD | 24-08-2012 | 30-04-2013 | 03-02-2014 | None |
| 61 | Female | Sarcoma | Yes | GD | 21-07-2017 | 31-08-2018 | 31-08-2018 | None |
| 38 | Male | Sarcoma | Yes | GD | 30-01-2015 | 06-03-2015 | 27-04-2015 | None |
| 44 | Male | Sarcoma | Yes | GD | 18-08-2016 | 27-10-2016 | 16-12-2016 | None |
| 80 | Female | Sarcoma | yes | GD | 10-02-2014 | 08-04-2014 | 12-05-2014 | None |
| 56 | Female | Sarcoma | Yes | GD | 21-02-2017 | 10-04-2017 | 09-05-2017 | None |
| 59 | Male | Sarcoma | Yes | GD | 04-06-2008 | 05-08-2008 | 05-09-2008 | None |
| 70 | Male | Biliary tract | Yes | GEM | 26-03-2007 | 14-05-2007 | 06-08-2007 | None |
| 60 | Male | DK | Yes | GEM | 04-02-2010 | 27-05-2010 | 09-09-2010 | None |
| 66 | Male | DK | Yes | GEM | 26-02-2010 | 17-09-2010 | 11-02-2012 | None |
| 78 | Female | DK | Yes | GEM | 09-02-2006 | 28-03-2006 | 02-05-2006 | None |
| 60 | Male | Pancreas | Yes | GEM | 12-11-2013 | 28-01-2014 | 04-06-2014 | None |
| 67 | Female | Pancreas | Yes | GEM | 08-11-2011 | 20-12-2011 | 20-12-2011 | None |
| 63 | Male | Pancreas | Yes | GEM | 05-11-2009 | 14-10-2010 | 18-01-2011 | None |
| 57 | Female | Pancreas | Yes | GEM | 30-09-2009 | 19-11-2009 | 18-06-2010 | None |
| 62 | Female | Pancreas | Yes | GEM | 20-11-2006 | 26-01-2007 | 15-04-2007 | None |
| 41 | Female | Pancreas | Yes | GEM | 13-04-2012 | 17-08-2012 | 09-01-2013 | None |
| 74 | Male | Pancreas | Yes | GnP | 12-02-2015 | 16-12-2015 | 12-01-2016 | None |
| 62 | Male | Pancreas | Yes | GnP | 05-06-2015 | 14-09-2016 | 20-01-2017 | None |
| 54 | Male | Pancreas | Yes | GnP | 10-04-2015 | 06-07-2015 | 22-01-2016 | None |
| 81 | Male | DK | Yes | GEM | 16-01-2015 | 03-06-2016 | 31-08-2018 | β-lactamase inhibitor |
Abbreviations: CUP, Cancer of unknown primary; NEC, Neuroendocrine carcinoma; GEM, Gemcitabine; GnP, GEM+nabPTX; GC, GEM plus cisplatin; GD, GEM plus docetaxel; GCS, GEM plus cisplatin plus S-1.