Fig 5. Heterogeneity is beneficial to growth during drug exposure.

In absence of drug pressure, monoculture growth (solid black line) for both WT and M1 is significantly faster than all three co-cultures of 10:90 (dashed blue line), 50:50 (dotted red line), and 90:10 (dashed-dotted yellow line) mixes of WT:M1. However, when exposed to docetaxel, bortezomib, and afatanib, co-culture heterogeneity is beneficial to both cell types, conferring faster growth than in the monoculture case. Top: model predictions of WT growth; bottom: model predictions of M1 growth.