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. 2019 Aug 26;14(8):e0221721. doi: 10.1371/journal.pone.0221721

Table 2. Hazard ratios (HRs) and 95% confidential intervals (CIs) for recurrence free survival (RFS).

Univariate analysis Multivariate analysis
HRs (95% CI) P value HRs (95% CI) P value
Age <0.001 <0.001
    >35 1 1
    ≤35 0.355(0.227–0.555) 0.416(0.256–0.674)
T stage 0.001 0.514
    1 1 1
    2 1.5661.005–2.442) 0.048 1.293(0.801–2.085) 0.293
    3 4.196(2.162–8.142) <0.001 1.740(0.833–3.635) 0.141
N stage <0.001 <0.001
    0 1 1
    1 1.694(1.066–2.690) 0.026 1.339(0.809–2.214) 0.256
    2 3.702(2.111–6.492) <0.001 2.938(1.601–5.393) 0.001
    3 5.313(3.057–9.232) <0.001 3.969(2.068–7.619) <0.001
LVI <0.001 0.272
    Negative 1 1
    Positive 2.377(1.468–3.848) 1.349(0.791–2.300)
HG 0.990
    I and II 1
    III 1.001(0.825–1.216)
A20 <0.001 <0.001
    Low 1 1
    High 2.672(1.710–4.175) 2.324(1.446–3.736)
ER 0.535
    Negative 1
    Positive 1.127(0.772–1.646)
PR 0.535
    Negative 1
    Positive 0.887(0.607–1.296)
HER2 0.862
    Negative 1
    Positive 0.954(0.560–1.624)
TNBC vs non-TNBC 0.842
    non-TNBC 1
    TNBC 1.042(0.692–1.570)

LVI, Lymphovascular invasion; HG, histologic grade; ER, estrogen receptor; PR, progesterone receptor; HER-2, human epidermal growth factor receptor-2; TNBC, triple negative breast cancer