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. 2019 Aug 26;14(8):e0221721. doi: 10.1371/journal.pone.0221721

Table 3. Hazard ratios (HRs) and 95% confidential intervals (CIs) for Overall survival (OS).

Univariate analysis Multivariate analysis
HR (95% CI) P value HR (95% CI) P value
Age 0.001 0.042
    >35 1 1
    ≤35 0.429(0.260–0.708) 0.536(0.325–0.978)
T stage <0.001 0.073
    1 1 1
    2 1.677(0.995–2.828) 0.052 1.340(0.763–2.355)
    3 5.751(2.836–11.662) <0.001 2.123(0.955–4.718)
N stage <0.001 <0.001
    0 1 1
    1 1.460(0.845–2.524) 0.175 1.128(0.619–2.053)
    2 3.847(2.086–7.093) <0.001 2.894(1.483–5.648)
    3 6.566(3.672–11.741) <0.001 4.067(2.027–8.162)
LVI <0.001 0.116
    Negative 1 1
    Positive 3.079(1.833–5.172) 1.595(0.891–2.856)
HG 0.492
    I and II 1
    III 1.080(0.867–1.344)
A20 <0.001 <0.001
    Low 1 1
    High 2.906(1.801–4.690) 2.629(1.585–4.361)
ER 0.292
    Negative 1
    Positive 0.793(0.515–1.221)
PR 0.330
    Negative 1
    Positive 0.808(0.526–1.241)
HER2 0.831
    Negative 1
    Positive 0.934(0.497–1.754)
TNBC vs non-TNBC 0.857
    Non-TNBC 1
    TNBC 1.045(0.645–1.693)

LVI, Lymphovascular invasion; HG, histologic grade; ER, estrogen receptor; PR, progesterone receptor; HER-2, human epidermal growth factor receptor-2; TNBC, triple negative breast cancer