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. 2019 Aug 14;15(8):e1008086. doi: 10.1371/journal.pgen.1008086

Fig 2. Phylogenetic analysis of mammal, plant and fungal DNA methyltransferases.

Fig 2

The maximum likelihood tree resolved five groups i) the Dnmt1/Met1/CMT group (orange), ii) the Dnmt2, group (black) iii) the Dnmt3/DRM group (red) iv) the fungal Dim2-like group (purple) and v) the fungal-specific Rid-like group (green), vi) the DNMT5 group (blue). Haemophilus aegyptius (HaeMTase: WP_006996493.1) Arabidopsis thaliana (ArathMet1: NP_199727.1; ArathCMT2: NP_193637.2; ArathCMT3: NP_177135.1; ArathDRM1: NP_197042.2; ArathDRM2: NP_196966.2), Ascobolus immersus (AscimMasc3: CE37440_11164; AscimMasc1: AAC49849.1; AscimDnmt5: RPA73956.1), Aspergillus nidulans (AspniDmtA: XP_664242.1, AspniDnmt5: XP_663680.1), Botrytis cinerea (BotciDim2: XP_024553164.1; BotciRid: XP_024550989.1, BotciDnmt5: XP_024550790.1), Cenococcum geophilum (CengeDim2: OCK96497.1; CengeRid: OCK89234.1), Coccidioides immitis (CocimDim2: XP_001247991.2; CocimRid: XP_001239116.2; CocimDnmt5: XP_001247253.2) Epichloe festucae (EpifeDim2: annotated in this study; EpifeRid: AGF87103.1), Fusarium graminearum (FusgrDim2: EYB34029.1; FusgrRid: XP_011320094.1) Pseudogymnoascus destructans (GeodeDim2: XP_024321957.1; GeodeRid: XP_024328520.1; GeodeDnmt5: XP_024320712.1) Magnaporthe grisea (MaggrDim2: XP_003718076.1; MaggrRid: XP_003720946.1) Mus musculus (MusmuDnmt1: NP_001300940.1; MusmuDnmt3A: NP_031898.1; MusmuDnmt3B: NP_001003961.2, MusmuDnmt2: NP_034197.3), Neurospora crassa (NeucrDim2: XP_959891.1; NeucrRid: AAM27408.1), Penicillium chrysogenum (PenchRid: XP_002563814.1; PenchDnmt5: XP_002561360.1), Podospora anserina (PaDim2: Pa_5_9100; PaRid: Pa_1_19440; PaDnmt5: Pa_4_2960), Pyronema confluens (Pyrco1dim2: PCON_02009m.01; Pyrco2dim2: PCON_01959m.01, PircoRid: PCON_06255m.01; PyrcoDnmt5: CCX08765.1), Schizosaccharomyces pombe (SchpoDnmt2: NP_595687.1), Thielavia terrestris (ThiteDim2: XP_003654318.1; ThiteRid: XP_003651414.1; ThiteDnmt5: XP_003650845.1), Trichoderma reesei (TrireDim2 XP_006964860.1; TrireRid: AEM66210.1), Trichophyton rubrum (TriruDim2: XP_003239082.1; TriruRid: XP_003239287.1; TriruDnmt5: XP_003236242.1), Tuber melanosporum (TubmeDim2: XP_002837027.1; TubmeRid: XP_002842459.1; TubmeDnmt5: XP_002837747.1).