Fig 1. Cytokine production by the 3-D model cells after stimulation with three different Salmonella enterica serovars.
3-D model cells were left untreated (none) or exposed to either Salmonella enterica serovar Paratyphi A (PA), Paratyphi B (PB), or Typhi (ST) strains. After 4 hours, the levels of IL-1β, IL-6, IL-8, TNF-α and CCL3 cytokines in the culture supernatants were measured by Meso Scale Discovery (MSD) multiplex-assays. Bar graphs extend from the 25th to 75th percentiles; the line in the middle represents the median of the pooled data. The whiskers delineate the smallest to the largest value. The data represent up to 8 individual experiments for each of the Salmonella strains with 2 or 3 replicates in each experiment. Horizontal lines represent significant differences (P<0.05) between the indicated culture conditions.