TABLE 1.
Baseline Characteristics of the Study Population
| All Patients (n = 4088) |
Group 1: eGFR <30 mL/minute/ 1.73 m2 or Dialysis (n = 937) |
Group 2: eGFR ≥30 mL/minute/ 1.73 m2 (n = 2812) |
Group 3: SLKT (n = 339) |
PValue for Trend |
|
|---|---|---|---|---|---|
| Sociodemographic data | |||||
| Age, years | 58±8 | 58±8 | 58±8 | 59±8 | 0.02 |
| Sex, male | 2236 (55) | 407 (43) | 1656 (59) | 173 (51) | <0.001 |
| Race/ethnicity | <0.001 | ||||
| Caucasian | 3420 (84) | 735 (78) | 2422 (86) | 263 (78) | |
| African American | 94 (2) | 24 (3) | 53 (2) | 17 (5) | |
| Hispanic | 455 (11) | 144 (15) | 261 (9) | 50 (15) | |
| Others | 88 (2) | 15 (2) | 64 (2) | 9 (3) | |
| Education level | 0.46 | ||||
| Completion of high school or lower | 1764 (43) | 401 (43) | 1210 (43) | 153 (45) | |
| Attendance of college or technical school | 810 (20) | 168 (18) | 576 (20) | 66 (19) | |
| Bachelor’s degree or higher | 903 (22) | 215 (23) | 604 (21) | 84 (25) | |
| Comorbidities | |||||
| Presence of diabetes mellitus | 2116 (52) | 483 (52) | 1403 (50) | 230 (68) | <0.001 |
| Presence of ascites | 3565 (87) | 847 (90) | 2414 (86) | 304 (90) | <0.001 |
| Malignancy | 0.02 | ||||
| No malignancy | 3577 (88) | 835 (89) | 2439 (87) | 303 (90) | |
| Malignancy present | 309 (8) | 58 (6) | 230 (8) | 21 (6) | |
| Uncertain or missing data on malignancy | 171 (4) | 25 (3) | 131 (5) | 15 (4) | |
| Functional status | <0.001 | ||||
| Able to perform normal activities | 955 (23) | 77 (8) | 818 (29) | 60 (18) | |
| Unable to perform normal activities | 2907 (71) | 788 (84) | 1848 (66) | 271 (80) | |
| Presence of TIPS | 446 (11) | 88 (9) | 325 (12) | 33 (10) | 0.43 |
| BMI, kg/m2 | 33±6 | 33±6 | 33±5 | 32±6 | 0.04 |
| Exception MELD score | 24±9 | 33±8 | 20±7 | 30±8 | <0.001 |
| Laboratory data | |||||
| Serum creatinine, mg/dL | 1.3 (1.0–2.1) | 2.7 (2.1–3.7) | 1.1 (0.9–1.4) | 3.4 (2.3–4.7) | <0.001 |
| Serum albumin, g/dL | 3.0 ± 0.7 | 3.1 ± 0.8 | 2.9 ± 0.6 | 3.0 ± 0.8 | <0.001 |
| Serum bilirubin, mg/dL | 4.1 (2.3–8.3) | 6.5 (3.2–19.1) | 3.8 (2.2–6.9) | 3.2 (1.7–7.6) | <0.001 |
| INR | 1.7 (1.4–2.2) | 1.9 (1.6–2.4) | 1.7 (1.4–2.1) | 1.7 (1.4–2.1) | <0.001 |
| Transplantation-related data | |||||
| Cold ischemia time, hours | 6.7 (5.0–8.3) | 6.5 (5.0–8.4) | 6.0 (5.0–7.7) | 6.0 (5.0–7.7) | 0.05 |
| Donor age, years | 43±17 | 41±17 | 44±17 | 37±15 | 0.67 |
| Donor sex, male | 2407 (59) | 532 (57) | 1662 (59) | 213 (63) | 0.29 |
| Donor race/ethnicity | 0.001 | ||||
| Caucasian | 2749 (67) | 609 (65) | 1903 (68) | 237 (70) | |
| African American | 769 (19) | 155 (17) | 562 (20) | 52 (15) | |
| Hispanic | 404 (10) | 118 (13) | 244 (9) | 42 (12) | |
| Others | 135 (3) | 36 (4) | 91 (3) | 8 (2) | |
| Donor BMI, kg/m2 | 28±6 | 27±6 | 28±6 | 27±5 | 0.05 |
| CMV mismatch | 0.047 | ||||
| Donor–/recipient– | 443 (11) | 98 (10) | 307 (11) | 38 (11) | |
| Donor– or donor+/recipient+ | 2485 (61) | 588 (63) | 1677 (60) | 220 (65) | |
| Donor+/recipient– | 862 (21) | 172 (18) | 630 (22) | 60 (18) | |
NOTE: Data are given as n (%), mean ± SD, and median (IQR).