Table 1.
Effect and predictive value of the Ocular Staining Score additional corneal points on classification for primary SSa
| SS (n = 445), n (%) | Non‐SS Sicca (n = 549), n (%)b | PPV (95% CI) | NPV (95% CI) | Odds Ratio (95% CI) | P | |
|---|---|---|---|---|---|---|
| Additional points (positive) | 201 (45) | 107 (20) | 0.66 (0.61‐0.71) | 0.65 (0.61‐0.69) | 3.66 (2.76‐4.85) | 1.65 × 10e‐20 |
| Confluent staining (positive) | 183 (41) | 83 (15) | 0.69 (0.63–0.74) | 0.64 (0.60‐0.67) | 3.92 (2.9‐5.29) | 2.44 × 10e‐20 |
| Pupillary staining (positive) | 138 (31) | 59 (11) | 0.70 (0.63‐0.76) | 0.61 (0.58‐0.65) | 3.37 (2.66‐5.23) | 1.25 × 10e‐15 |
| Filaments (positive) | 35 (8) | 16 (3) | 0.69 (0.54‐0.80) | 0.57 (0.53‐0.60) | 2.84 (1.55‐5.21) | 0.0005 |
Abbreviation: AECG, American European Consensus Group; CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value; SS, Sjögren syndrome.
a
SS classification is based on AECG criteria. We excluded all participants with secondary SS or overlap syndromes or those with incomplete ocular assessments 4.
b
Participants with non‐SS sicca are participants who have self‐described sicca symptoms and meet at least one AECG criterion but do not meet enough criteria to be classified as having SS.