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. 2019 Aug 10;11(15):5689–5704. doi: 10.18632/aging.102153

Table 2. Summary of databases used in this study.

Name Link This study Keywords
TCGAportal http://www.tcgaportal.org To investigate the expression of SPC25 in human tissues gene expression; 28 cancer types; survival curve; DNA methylation; mutation
FIREBROWSE http://firebrowse.org/ gene expression profile analysis profile
UALCAN http://ualcan.path.uab.edu/ To analyze the SPC25 mRNA expression in different races, ages, molecular subtypes of BC patients gene expression; 16 cancer types; survival curve; DNA methylation
Human Protein Atlas https://www.proteinatlas.org/ To detect SPC25’s distribution and subcellular localization proteins distribution; subcellular localization; impact for survival
CANCERTOOL http://web.bioinformatics.cicbiogune.es/CANCERTOOL/index.html To explore the relationship between SPC25 expression and relapse in BC 4 cancer types gene expression; genes correlation; functions and processes
Kaplan-Meier Plotter http://kmplot.com/analysis/index.php?p=background To analyzed the correlations between SPC25 mRNA expression and DMF, RFS as well as OS breast cancer; subtype; survival curve;
CancerSEA http://biocc.hrbmu.edu.cn/CancerSEA/ To observe the potential roles of SPC25 in BC 41,900 single cells 25 cancer types; 14 functional states;
Cistrome DB Toolkit http://dbtoolkit.cistrome.org Selected the TF of SPC25 - FOXM1 transcription factor; histone modifications
MEXPRESS https://mexpress.be/ To unearth the methylation details of SPC25 as well as the relationship between SPC25 mRNA expression and different clinical characteristics of BC gene expression; 34 cancer types; DNA methylation
GEPIA 2 http://gepia2.cancer-pku.cn/#index To assess the correlations between genes gene expression; survival curve; isoform details; genes correlation; similar genes detection
LinkedOmics http://www.linkedomics.org/admin.php To predict the miRNAs related to SPC25 32 cancer types; mRNA / protein expression; target genes; enrichment analysis
TargetScanHuman http://www.targetscan.org/vert_71/ gene; miRNA
starBase v3.0 http://starbase.sysu.edu.cn/index.php To predict the miRNAs related to SPC25; To perform circRNAs prediction, survival analysis of miRNAs as well as correlation analysis between miRNAs and SPC25 mRNA miRNA target; ceRNA network; RBP target; RBP motif; Pathway; Pan-cancer
Metascape http://metascape.org/gp/index.html#/main/step1 To obtained the heatmap and network of enrichment terms related to SPC25 gene annotation; membership search; functional enrichment; interactome analysis
STRING https://string-db.org/cgi/input.pl To obtain the interaction network between SPC25 and other important proteins protein details; interactive network; functional enrichment
DISIDB http://cis.hku.hk/TISIDB/index.php To analyze the correlations between expressions of SPC25 mRNA and 3 kinds of immune factors immune system; 30 cancer types; immunotherapy
RMBase v2.0 http://rna.sysu.edu.cn/rmbase/index.php To predict potential RBP of SPC25 mRNA RNA modification; RBP prediction; RNA - miRNA binding