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. 2019 Aug 5;11(15):5300–5318. doi: 10.18632/aging.102092

Figure 9.

Figure 9

Combination of miR-199a and hMSCs delivering miR-199a enhances the chemosensitivity of glioma cells to TMZ. (A–B) the migration ability of U251 cells, assessed by scratch test (Scale bar = 100 μM). (C–D) the invasive ability of U251 cells, measured by Transwell assay (Scale bar = 50 μM). (E–F) the proliferation ability of U251 cells, evaluated by EdU assay. (G–H) the glioma cell apoptosis, detected by TUNEL staining (Scale bar = 50 μM). * p < 0.05 compared with the mimic-NC + TMZ group; # p < 0.05 compared with the TMZ group. The results were measurement data, presented as mean ± standard deviation. Paired t-test was used for the analysis. The experiment was repeated three times. TMZ, cells treated with Temozolomide; mimic-NC + TMZ, cells treated with mimic-negative control and Temozolomide; miR-199a mimic + TMZ, cells treated with miR-199a mimic and Temozolomide.