Table 3.
Importance of Outcomes Relating to Diagnosis
| Survey Question | Clinicians (n=106) |
Patient Stakeholders (n=106) |
P-value |
|---|---|---|---|
| 1: In a person with NO memory/thinking problems, how important is it to predict whether someone will develop memory and thinking problems due to Alzheimer disease in the future? | 5 (IQR 2–7) Range 1–9 |
7 (IQR 6–9) Range 1–9 |
<0.001 |
| 2: In a person with mild cognitive impairment, how important is it to predict whether that person will develop more severe problems with memory and thinking (dementia) due to Alzheimer disease in the future? | 8 (IQR 7–9) Range 1–9 |
8 (IQR 7–9) Range 3–9 |
0.015 |
| 3: In a person with dementia (memory and thinking problems affecting daily life), how important is it to get an accurate diagnosis of Alzheimer disease? | 8 (IQR 6–9) Range 2–9 |
9 (IQR 8–9) Range 3–9 |
<0.001 |
| 4: In a person with dementia (memory and thinking problems affecting daily life), how important is it to exclude a diagnosis of Alzheimer disease? | 8 (IQR 6–9) Range 1–9 |
8 (IQR 6–9) Range 1–9 |
0.821 |
| 5: In a person with memory and thinking problems (dementia), how important is it to have a certain diagnosis of Alzheimer disease so that patients, families, and physicians can stop looking for other explanations/causes? | 8 (IQR 7–9) Range 1–9 |
8 (IQR 7–9) Range 2–9 |
0.432 |
| 6: In a person with memory and thinking problems (dementia) due to Alzheimer disease, how important is it to predict how fast he or she will worsen? | 8 (IQR 6–9) Range 1–9 |
8 (IQR 7–9) Range 3–9 |
0.003 |
| 7: In people with Alzheimer disease, a protein (amyloid) clumps in the brain. How important is it to know how much protein (amyloid) a person has built up in the brain, irrespective of symptoms/diagnosis? | 5 (IQR 2–6) Range 1–9 |
9 (IQR 7–9) Range 3–9 |
<0.001 |
Responses: Limited importance 1–3, important 4–6, critical importance 7–9. Data presented as median (interquartile range, IQR).